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    Chemical composition of medicinal plant Atractylis serratuloides
    (ELSEVIER, 2016-03-05) Chabani, Sonia; Haba, Hamada; Long, Christophe; Benkhaled, Mohammed
    Phytochemical investigation of the roots of Atractylis serratuloides Sieber ex Cass. (Asteraceae) led to the isolation of nine compounds 1–9 including eight triterpenoids and one phenolic compound. Their structures were established on the basis of physical and spectroscopic analysis, including 1D and 2D NMR (1H, 13C, COSY, HSQC, and HMBC), mass spectrometry ESI, and by comparison with those published in the literature. Triterpenoids are typical compounds of Atractylis genus and could be useful as characteristic markers in chemotaxonomic research. In addition, isolated triterpenoids have previously showed many biological activities and might explain the use of A. serratuloides in traditional medicine.
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    Three new oleanane-type triterpene saponins from Atractylis flava
    (ELSEVIER, 2015-12-11) Chabani, Sonia; Lavaud, Catherine; Benkhaled, Mohammed; Harakat, Dominique; Long, Christophe; Haba, Hamada
    Three new bidesmosidic saponins (1–3), along with thirteen known metabolites consisting of two flavonoids and eleven triterpenoids were identified in dichloromethane and n-butanol extracts of the whole plant Atractylis flava Desf. The saponins were characterized as 3-O-[β-d-glucuronopyranosyl]-28-O-[β-d-xylopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 2)-β-d-xylopyranosyl]-16α-hydroxygypsogenic acid (1), 3-O-[β-d-glucuronopyranosyl]-28-O-[β-d-xylopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 2)-α-l-arabinopyranosyl]-16α-hydroxygypsogenic acid (2), and 3-O-[β-d-galactopyranosyl-(1 → 2)-β-d-glucuronopyranosyl]-28-O-[((3-O-acetyl)-β-d-xylopyranosyl)-(1 → 4)-((2-O-acetyl)-α-l-rhamnopyranosyl)-(1 → 2)-β-d-xylopyranosyl]-quillaic acid (3). Structures of all isolated compounds were elucidated by spectroscopic analysis, including 1D and 2D NMR (1H, 13C, COSY, HSQC, TOCSY, HSQC-TOCSY, HMBC, ROESY and NOESY), high-resolution electrospray ionization mass spectrometry (HRESIMS), acid hydrolysis, measurement of optical rotation and comparison with literature data.