HNS-RE2SD Research Laboratories Documents
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Laboratories of the Higher National School of Renewable Energies, Environment and Sustainable Development
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Item Phytochemicals, Antihemolytic, Anti-inflammatory, Antioxidant, and Antibacterial Activities from Thymus Algeriensis(TAYLOR & FRANCIS LTD, 2021-03-12) Mokhtari, Mouna; Chabani, Sonia; Mouffouk, Soumia; Aberkane, Mohamed-Cherif; Dibi, Ammar; Benkhaled, Mohammed; Haba, HamadaThe chemical composition and anti-inflammatory, antihemolytic, antioxidant, and antibacterial activities of solvent extracts of Thymus algeriensis in petroleum ether, chloroform, and n-butanol were evaluated. Ten compounds including four flavonoids, four phenolics, and two triterpenoids were isolated and identified by chromatography and spectroscopy. The n-butanol extract had the greatest antioxidant activity and inhibited hemolysis with a value of IC50 at 322.85 ± 0.87 µg mL−1. The chloroform extract exhibited the highest anti-inflammatory effect with 45.27% inhibition. The extracts demonstrated antibacterial activity against the tested strains.Item A new 7,9′-monoepoxylignan glucoside and other phytochemicals from Centaurea granatensis and their chemotaxonomic significance(PERGAMON-ELSEVIER SCIENCE LTD, 2024-07-30) Belaid, Meriem; Mouffouk, Soumia; Chabani, Sonia; Mouffouk, Chaima; Benkhaled, Mohammed; Haba, HamadaThe chemical study of Centaurea granatensis Boiss. ex DC. allowed the isolation and structural elucidation of eighteen secondary metabolites (1-18) from ethyl acetate (EtOAc) and n-butanol (n-BuOH) extracts. These compounds are divided into one new epoxylignan glucoside (1) and seventeen known phytochemicals including seven flavonoids (2-8), four triterpenes (9-12), and six phytosterols (13-18). Structures of the isolates were identified using various spectroscopic methods, namely 1D NMR (1H and 13C), 2D NMR (HSQC, 1H-1H COSY, HMBC, and NOESY), and mass spectrometry (HR-ESIMS), as well as by comparison with literature data. The obtained results showed the abundance of triterpenoids and flavonoids particularly flavones in C. granatensis. Apigenin (3) could be used as a chemotaxonomic marker of this genus due to its presence in approximately forty plant species. Furthermore, tiliroside (2) and stigmasteryl-3-O-β-D-glucoside-6′-palmitate (18) were first detected in Centaurea genus, but had previously been found in species of the Asteraceae family. Additionally, the chemotaxonomic significance of all isolated molecules was fully discussed.